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O. Kerbarh, A. Ciulli, N. I. Howard and C. Abell, J. Bacteriol., 2005, 187, 5061–5066 CrossRef CAS PubMed. Chemical probes can be used to help establish the relationship between a molecular target and the broader biological consequences of modulating that target in cells or organisms. They can also help you discover new biology relating to that target, to clarify the relationship between the target and a phenotype, and to validate that a particular target is a suitable intervention point to impact the progression or outcome of a disease. Chemical probes offer a biological rather than a clinical validation of the target. This usage of chemical probes, while consistent with recent drug discovery terminology, should not be confused with probes used in genomics research—DNA or RNA sequences labeled with fluorescent or radioactive tags that can be used to search for their complementary sequences in a sample genome.

T. L. Nikolakopoulou, S. Egan, L. S. van Overbeek, G. Guillaume, H. Heuer, E. M. H. Wellington, J. D. van Elsas, J. M. Collard, K. Smalla and A. D. Karagouni, Curr. Microbiol., 2005, 51, 211–216 CrossRef CAS PubMed. The series centers on World Securities Corporation, a high-tech international private investigation company that employs field operatives, the elite of whom, probes, are aided by implanted audio receivers and scanners, tiny video camera/ telemetry units which can be attached to tie clips or other jewelry. A common method is to wear the scanner on a ring, enabling it to be discreetly aimed. The apparent suicide of an alleged embezzler, whose widow hires Probe to investigate, leads Bianco to infiltrate a most unusual travel agency: a front for a criminal counterpart to the Witness Protection Program. Diana Muldaur and Sebastian Cabot are prominent guest stars. M. Pérez, F. Lombó, L. Zhu, M. Gibson, A. F. Braña, J. Rohr, J. A. Salas and C. Méndez, Chem. Commun., 2005, 12, 1604–1606 RSC.J. D. Rudolf, X. Yan and B. Shen, J. Ind. Microbiol. Biotechnol., 2016, 43, 261–276 CrossRef CAS PubMed. T. Lukežič, U. Lešnik, A. Podgoršek, J. Horvat, T. Polak, M. Šala, B. Jenko, P. Raspor, P. R. Herron, I. S. Hunter and H. Petković, Microbiology, 2013, 159, 2524–2532 CrossRef PubMed. Soupy Sales / The Carpenters / Route 66 / Bozo / The Carpenters Christmas Specials / Local Kid Shows / Death of TV's Superman / Wonderama / Sesame Street / Bob Hope Specials / Little Rascals / 1980's Retro Gay T-Shirts / 1980's TV Wrestling / Fess Parker / Howdy Doody /

Pan-assay interference (PAINS) properties to avoid include covalent reactivity, redox activity, and colloidal aggregation.

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Albert Popwell as Albert Griffin, linguist and code-breaker; former chief translator at the United Nations Probe agents report to V.C.R. Cameron ( Burgess Meredith), the director of the investigations, who runs Probe Control, a center reminiscent of the NASA Mission Control Center. "Cam" is the leader of the expert team who monitors and provides the agent with intelligence. In Italy the series aired under the title Search. It was called Operación Rescate (Rescue Operation) in Argentina. In Brazil the series aired on TV Globo under the title Controle Remoto (Remote Control). M. Hatsu, T. Sasaki, H. Watabe, S. Miyadoh, M. Nagasawa, T. Shomura, M. Sezaki, S. Inouye and S. Kondo, J. Antibiot., 1992, 45, 320–324 CrossRef CAS PubMed. The most difficult and sensitive assignments fall to the W.C.C.'s supersecret branch: Programmed Retrieval Operations, referred to as "Probe." The agents of Probe rival those of the CIA or MI-5, and are equipped with unique devices that even real-life 21st-century spooks would envy.